Cocaine- and amphetamine-regulated transcript (CART) peptide fragment that inhibits food intake. Attenuates NPY-induced feeding and decreases food intake in food-restricted goldfish, and induces anxiogenic-like effects in elevated plus-maze test in rats. Modulates the activity of striatal noradrenergic, and corticostrial and hypothalamic serotoninergic systems, with no major effect on dopaminergic pathways in rat brain.

Lofepramine is a potent tricyclic antidepressant that is extensively metabolized to desipramine.

Chlorprothixene is a typical antipsychotic drug of the thioxanthene class and was the first of the series to be synthesized.